Dr Katerina Pattichis MBBS BSc MSc PhD FIBMS


Platelets and wound healing


Normally our bodies are able to heal wounds naturally, however the ability of the body’s to heal is affected by many factors such as 

  • ageing
  • smoking
  • diabetes
  • obesity
  • high blood pressure
  • poor or compromised blood flow

In order for a wound or injured tissue to heal, a complex and precisely regulated series of natural processes are involved in the body with platelets playing an important mediator role. 

Platelets are produced in the bone marrow and they are the smallest kind of blood cell. When a blood vessel is injured, platelets gather at the site of injury (forming a platelet plug) to stop the bleeding and activate the coagulation cascade for blood clotting. Platelets also release various growth factors that aid in wound healing. 

Wounds that are no longer healing may have stopped attracting sufficient platelets and wound healing growth factors, to the injured site. 

By using the platelets from your own blood we can help trigger the natural wound healing process.

Advanced Technologies


Using advanced technologies, such as the RAPID Biodynamic Haematogel Chronic Wound Treatment protocol in conjunction with the Angel Concentrated PRP Blood Processing System, we are able to treat a range of wounds including:

  • Diabetic and neuropathic foot ulcers 
  • Abscesses
  • Vascular wounds
  • Slow or non-healing surgical wounds
  • Arterial and venous leg ulcers 
  • Surgical wounds

When the Arthrex Angel System is combined with Arthrex activAT, it is also possible to prepare platelet-rich fibrin gel (PRF gel), thus expanding the range of applications.

Evidence-based treatments


In conjunction with our partners, Biotherapy Services Ltd, we have carried out several Case Series and Pilot Wound Care Studies on the effect of PRP on wound closure. We have shown that addition of PRP to the standard multi-disciplinary care of patients with diabetic wounds is associated with rapid wound closure and low amputation rates. We have obtained National Institute of Clinical Excellence (NICE) approval and are currently conducting large scale clinical trials in several NHS hospitals in the UK to demonstrate the time and cost savings of our treatment to the NHS.

PRP induces upregulation of regulatory active cell cycle proteins. The antibacterial effect of PRP has also been demonstrated. Studies have shown that PRP accelerates new tissue formation effectively for various wounds/ulcers.